MRI BRAIN WITH SPECTROSCOPY
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Certified Labs
NABH Accredited
Reports in
6hrs
Measures
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About The Test
What is MRI Brain with Spectroscopy?
- Combines Magnetic Resonance Imaging (MRI) pictures with Spectroscopy data.
- Maps brain structure and chemical makeup in one session.
- Uses strong magnets—no radiation.
How the Test Combines Magnetic Resonance Imaging and Spectroscopy
- MRI captures detailed anatomical images.
- Spectroscopy adds metabolic peaks that reveal levels of key brain chemicals.
- Software overlays both datasets for a complete diagnostic picture.
Key Uses in Clinical Practice
- Characterize brain tumors (benign vs malignant).
- Pinpoint epilepsy seizure focus.
- Evaluate metabolic and mitochondrial disorders.
- Differentiate infection from tumor.
- Monitor chemotherapy or radiation response.
List of Parameters
- NAA (N-Acetylaspartate) – marker of healthy neurons.
- Choline (Cho) – high in rapidly dividing cells (tumor).
- Creatine (Cr) – internal reference peak.
- Lactate – signals anaerobic metabolism (ischemia/tumor).
- Lipid – indicates necrosis or infection.
- Myo-inositol – raised in Alzheimer’s and gliosis.
- Glutamate-Glutamine Complex – altered in epilepsy.
Why This Test
- Brain tumor characterization: Distinguish glioma from lymphoma.
- Epilepsy focus localization: Identify temporal lobe sclerosis.
- Metabolic disorder evaluation: Detect mitochondrial disease.
- Infection or abscess differentiation: Spot tuberculoma vs cysticercosis.
- Treatment response monitoring: See if tumor is shrinking or necrotic.
When to Take Test
Benefits
Benefits of Taking the Test
- Non-invasive metabolic brain assessment—no needles into the brain.
- Early detection of malignancy before symptoms worsen.
- Guiding biopsy or surgery planning—hit the most aggressive area.
- Monitoring therapy effectiveness—adjust chemo in real time.
Illnesses Diagnosed with MR Brain with Spectroscopy
- Gliomas and Glioblastomas.
- Metastatic brain lesions.
- Temporal lobe epilepsy.
- Mitochondrial disorders (e.g., MELAS).
- Radiation necrosis vs recurrence after cancer therapy.
Preparing for test
Fasting Requirements
- 4-hour fast if contrast is planned.
- Water is allowed; stay hydrated.
Metal Implant Screening
- Bring device card for any implant.
- Inform staff about orthopedic screws, dental implants, or tattoos with metallic ink.
Clothing and Jewelry Guidelines
- Wear cotton clothes without metal zippers.
- Leave jewelry, watches, and phones in lockers.
Pre-requisites
- Recent creatinine test (within 4 weeks) if gadolinium contrast is expected.
- Pregnancy screening for women of child-bearing age.
- Bring previous imaging CDs and reports for comparison.
Best Time to Take the MRI Brain with Spectroscopy
- Morning appointments preferred for diabetic patients—stable blood sugar.
- Avoid caffeine 4 hours prior to reduce motion.
- Schedule after initial MRI findings to target specific areas.
Eligibility
- Age: Infants to elderly (neonatal coil available).
- Weight limit: Up to 180 kg on our wide-bore scanner.
- Exclusions: Cardiac pacemaker, cochlear implant, recent vascular clips.
Procedure for Taking an MRI Brain with Spectroscopy
Check-in and Safety Screening
- Arrive 30 minutes early.
- Fill out safety questionnaire and metal checklist.
Positioning and Coil Placement
- Lie on the table; a head coil fits like a helmet.
- Cushions and earplugs provided for comfort.
Scan Duration (45–60 minutes)
- Routine MRI: 25–30 min.
- Spectroscopy add-on: extra 15–20 min depending on technique.
Post-Scan Care Instructions
- Resume normal activities immediately if no sedation.
- If sedated, rest in recovery for 30 minutes—bring an escort.
Caution Before Taking the Test
- Report allergies, especially to gadolinium or shellfish.
- Discuss anxiety medication 24 hours prior if claustrophobic.
- Double-check pockets—remove coins and credit cards.
Test Results
Results and Interpretations
Metabolite | Finding/Observation (Change from Normal) | General Interpretation/Significance |
---|---|---|
NAA/Cr | 1.5–2.5 | Low suggests neuronal loss |
Cho/Cr | <1.0 | Elevated = high cell turnover (tumor) |
Lactate | Absent | Present = ischemia or malignancy |
Lipid | Absent | Present = necrosis or infection |
Creatine (Cr) | Relatively Stable | Marker of energy metabolism; often used as a reference for calculating metabolite ratios. Typically remains stable across pathologies. |
Reduced NAA | Neuronal injury | Seen in neurodegenerative diseases |
Elevated Choline | High cellularity | Suggests tumor or inflammation |
Lactate Doublet | Anaerobic metabolism | Indicates ischemia or tumor |
Cho/NAA Ratio | ↑ Increased | Strong indicator of tumor activity—elevated due to increased choline (cell turnover) and decreased NAA (neuronal loss). |
Cho/Cr Ratio | ↑ Increased | Suggests elevated membrane turnover relative to energy metabolism; common in tumors and demyelination. |
NAA/Cr Ratio | ↓ Decreased | Reflects neuronal damage or loss compared to stable energy metabolism. |
Lactate/NAA Ratio | ↑ Increased | Suggests anaerobic metabolism in the context of neuronal injury—useful in assessing stroke, tumors, and mitochondrial dysfunction. |
Risks & Limitations
Magnetic Field Safety Precautions
- Pacemakers, cochlear implants, and neurostimulators may be contraindicated.
- All jewelry, hairpins, and hearing aids must be removed.
Claustrophobia and Anxiety Concerns
- Open-bore 3T scanner at Cadabams Diagnostics reduces claustrophobia.
- Mild oral sedatives available with prior consent.
Spectral Resolution Limitations
- Small lesions (< 5 mm) may yield unclear spectra.
- Movement artifacts can distort results—stay still!
FAQs
Is MRI Brain with Spectroscopy painful?
No. It is non-invasive and painless.
How long does the scan take?
Total session: 45–60 minutes; spectroscopy adds 15–20 minutes.
Can I eat before the test?
Light meal allowed; 4-hour fast only if contrast is planned.
Will I need contrast injection?
Not always. The neurologist will decide based on first images.
When will I get my results?
Preliminary report within 24 hours; full analysis by 48 hours.
What is the main difference between a regular brain MRI and one with Spectroscopy?
A regular brain MRI primarily shows the brain's physical structure and anatomy (e.g., size, shape, location of lesions). MR Brain with Spectroscopy provides functional information by measuring the levels of different chemicals (metabolites) within brain tissue, offering insights into its metabolic state, cell types, and viability.